AG in COMT's Val/Met variation, meaning Val/Met , intermediate speed of dopamine reuptake, and intermediate dopamine levels.
CT in rs4633, intermediate levels of the COMT protein and protection from endometrial cancer, intermediate pain sensitivity
CT in COMT's rs4646312, slightly higher odds of schizophrenia (Odds ratio 1.25 per risk allele, pval 8 x 10-6). Risk allele is C
GG in COMT's rs6267, which is the typical for most humans and leads to slightly lower risk of Schizophrenia
AA in COMT's rs165599 variation, which leads to a decreased risk of Schizophrenia and Bipolar disorder.
GG in rs3027452,higher level of MAOB enzyme - typical genotype. Tryptophan more effective for depression.
TT in MAOB's rs1799836; Higher odds of ADHD, Parkinson's, One study found lower odds of Schizophrenia
GG in MAOB's rs6324, typical (lower) ADHD risk, most common genotype
AA in MAOA's rs1800659, lower odds of post-surgical pain.
GG in MAOA's rs979605, decreased MAOA activity, worrier .
CC in MAOA's rs766117, higher odds of depression
Less D2 dopamine receptors 7.895 %.
Intermediate number of D2 dopamine receptors 36.842 %.
Higher number of D2 dopamine receptors 55.263 %.
GG, which means no derived No-Go Learner variants in DRD2's Pro319Pro variation, which means a higher number of D2 receptor sites in the brain, and a higher likelihood of schizophrenia
GG in rs6279 of DRD2, higher odds for Schizophrenia and less resistence to pain
AA in DRD2's rs6275 variation, meaning increased number of dopamine D2 receptors and a higher risk of Schizophrenia.
CC in DRD2's rs2514218, higher odds of Schizophrenia
AA genotype in rs4648317 of DRD2, which is implicated in an increased number of Dopamine D2 receptor sites in the brain and an increased likelihood of Schizophrenia.
GG in Taq1 variation of DRD2, which is the typical for most humans leading to a slightly higher number of D2 dopamine receptors, and to a slightly lower risk of ADHD and Alcoholism.
CC in DRD2's rs12363125, lower odds of cocaine dependence and migraine, higher D2 receptor availability
AA in DRD2's rs6589377, higher (typical) odds of neuroticism, but lower odds for nicotine dependence.
CC in rs1076560 of DRD2, which is the typical for most humans leading to a slightly higher number of D2 dopamine receptors and better memory performance.
TC, or heterozygous in rs5326 of DRD1, which is implicated in slightly higher odds of bipolar disorder andd schizophrenia.
AA in rs686 of Dopamine Receptor D1 gene, which leads to a higher likelyhood of Autism.
TT in rs4532 of DRD1, a typical associated with slightly higher odds of Autism and tobacco addiction.
GG in rs265981 of DRD1, which is the typical for most humans, and leads to a slightly higher risk of Schizophrenia and nicotine dependence.
CT in DRD1's rs4867798, one allele for reduced risk of schizophrenia according to 2014 study (T), one allele for higher odds of impulsive-compulsive behavior in those affected by Parkinson's disease (C)
AG in DRD1's rs265974, average odds of substance use disorders, risk allele is G.
TG in DRD1's rs265976, Patients with schizophrenia may have a poorer response when treated with clozapine as compared to patients with the GG or TT genotype. Other genetic and clinical factors may also influence response to clozapine.
TC, or heterozygous in rs6280 of DRD3, which is implicated in slightly higher risk of OCD and intellectual disability.
AA in DRD3's rs167771 variation, mostly a Eurasian genotype , increases the risks of autism and autistic personality traits such as rigid behavior.
AG in DRD3's rs963468, higher odds of schizophrenia, risk allele is A (doesn't play a role in the polygenic risk score calculation).
AC in rs11246226 of DRD4,which is a typical human that leads to slightly lower likelyhood of Schizophrenia.
No risk variants for mental retardation in DRD4's rs752306 (CC)
GG in DRD4's rs936461, lower odds of schizophrenia but slightly higher odds of various eating disorders(OR=1.35).
Lower levels of 5-HT (Serotonin) 15.000 %.
Intermediate levels of 5-HT (Serotonin) 55.000 %.
Higher levels of 5-HT (Serotonin) 30.000 %.
TC, or heterozygous in rs2129785, a rare that leads to long form 5-HTTLPR and a significantly lower risk of depression.
CT in rs6311 of HTR2A, slightly increased risk of suicidal behavior and depression. Normal risk of sexual dysfunction when taking SSRI Antidepressants.
AG in rs6313 of HTR2A, Typical odds for suicidal ideation
AG in HTR2A's rs2070040, G allele is associated with lower resistance to stress, irritability, and agressive behavior.
AA in rs17144465, typical (lower) depression risk.
AA in ESRRG's rs2377360, lower odds of depression
TT in rs364477, reduced odds of unipolar depression
CT in rs9834970 of TRANK1, average odds of Bipolar disorder and Schizophrenia
TT in DISC1 rs1411771, somewhat lower odds of bipolar and schizophrenia (does not play a role in polygenic risk scores)
GG in rs75459873, no risk variants for psychosis in MIR378F. Very typical genotype.
AG in ADCY2's rs17826816, higher odds of bipolar disorder.
Results Mental Health - Autism Only
Higher Odds of Autism 58.333 %.
Intermediate Odds of Autism33.333 %.
Lower Odds of Autism8.333 %.
TT in rs4307059, 1.42x risk of Autism, worse cell adhesion in neurons.
TT in rs10513025, typical , normal (higher) risk of autism.
CC in rs921451, lower tendency to smoke heavily if is a smoker.
TT in rs1451371, More likely to smoke heavily if is a smoker.
Results For Lactose Persistence
GG in MCM6's rs4988235 variation, which means this individual does not carry the European lactose persistence mutation.
TT in rs2322659 of LCT, likely lactose intolerant
Results for OXTR - The Empathy Gene
Lower Empathy 20.000 %.
Average Empathy 40.000 %.
Higher Empathy 40.000 %.
TG in rs237885, one 'sociopath' variant and one 'empath' variant in OXTR.
GG in rs1042778 of OXTR, higher oxytocin and empathy
Results for Diabetes
CC in rs6679677; normal(lower) risk for Rheumatoid Arthritis and Type 1 Diabetes
AA in HLA's rs9272346, Type 1 Diabetes very unlikely.
TT in rs7202877, slight decrease in risk of Type 1 Diabetes.
GG in rs12255372, decreased risk of Type 2 Diabetes.
AA in rs17696736, slighly lower odds of type 1 Diabetes
GG in rs35011184, lower odds of Type 2 diabetes and obesity.
GG in rs2476601 variation, which leads to lower risk of various autoimmune disorders and type 1 diabetes.
AG in rs17388568, 1 risk variant (A), 1.3x risk of type-1 diabetes.
CC in rs9273363, which leads to a 7 fold decrease in the risk of type 1 diabetes.
CC in rs7754840, which means this individual has two variants for higher odds of type 2 diabetes.
CC in rs7903146, a associated with lower risk of type 2 diabetes.
TG in rs4402960, leading to slight increase in the risk of Type 2 Diabetes.
Results for Hemochromatosis
GG in HFE's His63Asp, which means this individual has two copies of the H63D variant and likely suffers from hemochromatosis.
AA in HFE's S65C variation, which means that this individual does not carry any risk variants for hemochromatosis.
Results for Alzheimers
CC in rs7412, which means no APOE2 alleles in Arg176Cys variation of the APOE gene and lower, or in other terms, normal odds of alzheimers disease.
GG in PLD3's rs145999145 variation, which means this individual has a lower risk of Alzheimers.
TT in rs669, which leads to slightly decreased risk of Alzheimers.
AA in TOMM40's rs2075650, slightly decreased odds of Alzheimer's disease.
CC in rs75932628, normal (Slightly lower) risk of Alzheimer's disease
CC in rs63750847, no variants for reduced risk of Alzheimer's disease. Normal (Higher) odds of Alzheimers
Multiple sclerosis
(Linked) likely no HLA-DRB1*1501 alleles, typical , normal (lower) risk for MS. Lower (typical) odds for narcolepsy as well.
No risk variants in HLA-DQA1; lower risk of MS
no HLA-DRB1*1501 alleles, typical , normal (lower) risk for MS.
0 risk variants for MS in HLA-DRB1. Typical
AA in rs4959039, 2 (common) risk variants for MS.
Cardio-Vascular Disease Panel
AA in rs662799, normal (Lower odds of heart attack and obesity)
GG in rs602633, 0 risk variants for Coronary Heart Disease (Odds ratio = 1.11 for every T allele). common genotype.
GG in rs700651, ~20% higher risk of brain aneurysm, risk allele is G
GG in rs10958409, normal (lower) risk of brain aneurysm, risk allele is A
CC in rs1333040, lower odds of brain aneurysm and heart attack, risk allele is T.
AA in rs9298506, normal (higher) risk of aneurysm.
CC in rs6475606, much lower risk of Coronary artery disease.
CC in rs10757272, Normal (lower) risk for Coronary artery disease.
CC in rs9315204, lower risk of aneurysm, common genotype.
AA in rs10757274, normal(lower) risk of heart disease.
AA in rs2383206, normal(lower) risk of heart disease.
AA in rs10757278, 0.78x reduced risk for Coronary Heart Disease. 0.77x reduced risk for Brain Aneurysm and Abdominal Aortic Aneurysm..
AG in rs5082, slightly reduced risk of heart disease (G allele reduces risk).
AG in rs17576, average odds of heart attack and lung cancer.
Asthma + Epilepsy Panel
CT in rs7216389, Normal risk for Childhood Asthma. Risk varian is T
AG in rs1695, mixed evidence showing either increased or decreased risk of asthma
CC in rs10496964, typical (higher) odds of epilepsy
CC in rs7587026; decreased (typical) odds of epilepsy
AG in rs12059546, higher than average odds of epilepsy
AG in rs72823592, higher than average odds of epilepsy
Myopia Panel (Ordered from highest to lowest impact)
AA in rs12193446, which is the typical and leads to slightly increased risk of myopia, or nearsightedness.
AC in rs7744813, which leads to a slight increase in the risk of myopia.
AT, or heterozygous in rs524952, which means a slightly decreased risk of myopia.
AC in rs4803455, one allele that protects from Myopia.
CC in RBFOX1's rs17648524, higher odds of myopia.
Facial Morphology Panel
AA genotype in EDAR's rs3827760, Likely no shovel shaped incissors and not East Asian in ancestry
AA in rs6542787, 2 European EDAR alleles. Likely a European with European facial morphology
AA genotype in EDAR's rs260690, European facial traits. Very uncommon genotype for East Asians. Typical for Europeans.
CC in rs892540, longer (typical) midface length
AG in PAX3s rs7559271, intermediate odds of protruding nasal bridge, A allele increases the odds of protruding nasal bridge
CC in rs938036, likely has mandibular third molar, lower odds of tooth agenesis (missing teeth)
AG in rs7702108, intermediate eyebrow thickness
Miscellaneous
(Don't voice this in video!!) CC in rs9332964, no micropenis.
CC in rs10784502, increased cranial size and 2% higher IQ.
CT in rs28379706, slightly higher IQ.
AG in rs324640, 4 points higher IQ than individuals with 'AA' .
AT , 1 'fat gene' variant in FTO's rs9939609. Higher odds of obesity and sleep apnea.
TT in rs10427255, likely does not have photic sneeze reflex.
GG in SCN9A rs6746030 variation, no variants for increased pain sensitivity.
TT, no MYBPC2 mental retardation variants, likely healthy.
AA genotype in EDAR's rs3827760, Likely no shovel shaped incissors and not East Asian in ancestry
AA genotype in EDAR's rs260690, European facial traits. Very uncommon genotype for East Asians. Typical for Europeans.
GG in rs671 variation, Not an Asian flusher, lower odds of Alcoholism. Normal risk of Esophageal Cancer.
Drug Responce
Risk of Heart Failure Due to Beta Blocker Medications is 1.627 times the average.
When treated with metoprolol
Relative to AA in rs1801252 & GG in rs1801253 Genotypes :
rs1801252(A;A) and rs1801253(C;C) carriers: 15 point drop in Blood Pressure rs1801252(A;G) and rs1801253(C;C) carriers: 9 point drop in Blood Pressure rs1801252(A;A) and rs1801253(C;G) carriers: 6 point drop in Blood Pressure rs1801252(A;G) and rs1801253(C;G) carriers: 1 point drop in Blood Pressure
Your genotypes are : AG in rs1801252 & GC in rs1801253
GG in rs637644, higher odds of hair loss from chemotherapy.
AG in rs594206, 1 allele for lower odds of hair loss from chemotherapy (G).
TG in DRD1's rs265976, Patients with schizophrenia may have a poorer response when treated with clozapine as compared to patients with the GG or TT genotype. Other genetic and clinical factors may also influence response to clozapine.
AG in rs2273697, Adverse reaction more likely to carbamazepine in epileptic patients
TT in rs2298383, no variants for increased anxiety in response to caffeine.
AA in rs762551, Faster caffeine metabolism in smokers and heavy coffee consumers
CC in rs3892097, extensive CYP2D6 metabolizer
CT in rs1467558, higher risk of liver toxicity from acetominophen/tylenol/APAP
CT in rs10156191 of AOC1, decreased DOA activity, may not tolerate NSAIDs so well. The risk allele is T. This is a fairly common genotype.
TT in rs12476047. Lower than average odds of parkinson's symptoms when treated with antipsychotics
TT in rs5092, more likely to gain weight if taking olanzapine.
TC, or heterozygous in rs4765623, more likely to gain weight if taking olanzapine.
CC in rs3813929, higher odds of weight gain if taking olanzapine.
GG in rs518147, significantly higher odds of weight gain if taking olanzapine.
TT in AKT1's rs2494732, lower odds of Cannabis induced psychosis.
AG in rs2241802, average odds of methamphatamine induced psychosis.
CC in rs135745, higher susceptibility to methamphetamine induced psychosis.
Albinism & Atypical Traits Panel
CC in OCA2's rs121918166, Not Carrier of an oculocutaneous Albinism Type II mutation.
TT in rs61754381, which means not a carrier for 1B Tyrosinase-negative oculocutaneous albinism.
CC in TYR's rs104894313, Not Carrier of an oculocutaneous Albinism Type 1B mutation.
CC in rs987525, which leads to decreased risk of cleft lip and palate.
Familiar Mediterranean Fever Panel
0 risk variants in rs3743930.
0 risk variants in rs11466023
0 risk variants in rs104895081
0 risk variants in rs104895157
0 risk variants in rs11466024
0 risk variants in rs11466026
0 risk variants in rs79681911
0 risk variants in rs4149584
MTHFR panel
AG in MTHFR's rs1801133, 65% efficiency in processing folic acid. Slightly higher than average odds for a variety of illnesses from autism to coronary heart disease.
GG in rs2066470, typical genotype.
TT in MTHFR's rs1801131, most common genotype , lower odds of various health issues.
AA in rs17367504, common , average (higher) blood pressure.
Cancers Panel
0 risk variants in Q356R of BRCA1
0 risk variants in BRCA1's D693N.
0 risk variants in S1140G of BRCA1
0 risk variants in K1183R of BRCA1
0 risk variants in S1613G of BRCA1
0 risk variants in N372H of BRCA2
CG in rs1042522 of TP53. common genotype. Slightly increased lifespan. Average odds of various cancers.
0 risk variants in S707P
AG in Estrogen Receptor 1 Gene's -351A>G variation. Women have normal (lower) risk of Endometriosis, 0.75x lower risk of Endometrial Cancer, and normal (higher) risk of cognitive impairment.
GG in rs995030, common , slightly higher risk of testicular cancer.
AA in rs4474514, >3x increased testicular cancer risk for men
Leukemia Panel
GT in rs4132601, somewhat (1.7x) increased risk for acute lymphoblastic leukemia.
TT in rs7089424, common/normal and lower risk of Leukemia.
AG in rs2239633, average odds of leukemia.
Rare diseases/traits Panel
GG in rs75801644, 0 risk variants for endometriosis.
AA in F9 rs137852229, not a Carrier of a Hemophilia B mutation - 0 risk variants
TG in rs9540294, 2.6x odds of Recalcitrant atopic dermatitis, rare risk allele is G
CC in rs41280169, 0 risk variants for panic disorder (very common genotype)
GG in rs79919349, 0 risk variants for panic disorder (very common genotype).
No predisposition to hemoglobin E disease, TT in rs2071348
CC in rs119478057, no predidposition to Hypercarotenemia and vitamin a deficiency
GG in rs387906725, no Lesch-nyhan syndrome.
TT in rs121434622, no Fragile X syndrome
GG in rs61816761, normal (no dermatitis)
GG in rs74315329, not a carrier for Glaucoma (primary open-angle).
AG in rs893818, average odds of Exfoliation glaucoma.
AG in rs3825942, possibly lower glaucoma risk.
AA in rs16863657, lower odds of neural tube defects, typical genotype.
GG in rs80338794, not a Finnish major Salla disease mutation carrier - 0 risk variants.
Found 0 risk variants for Holoprosencephaly in GLI2. Very typical/common genotype
GG in rs34536443, typical (lower) odds of tuberculosis infection, common genotype
CC in rs2200733, 0.86x decreased risk of Atrial Fibrillation
GG in rs660895, 4-6x risk of rheumatoid arthritis. Significantly increased risk of IgA nephropathy - a disease in which IgA protein builds up in and damages the filtering part of the kidney (glomerulus)
AC in rs7743761, 4.6x increased risk of Ankylosing Spondylitis. Risk allele is A.
TT in rs6457617, 5.2x risk of rheumatoid arthritis and 1.5x risk of systemic sclerosis, very uncommon genotype.
TG in rs11090865, Carrier of a deafness-related modifier variant
GG in rs13078881, Healthy - no Biotinidase deficiency.
TT in rs6151429, healthy
TT in rs4794067; Lower risk of Aspirin Induced Asthma. Normal (higher) risk of lupus and intractable Grave's Disease.
CT in rs10156191 of AOC1, decreased DOA activity, may not tolerate NSAIDs so well. The risk allele is T. This is a fairly common genotype.
CC in rs104894635, no risk variants for Sanfilippo syndrome
CC in rs1800546, normal.
AA in rs3764147, 0 risk variants for leprosy.
GG in rs11606250, most common , but higher risk for certain autoimmune diseases.
Celiac Disease Panel
average, no HLA-DRB1*0301 alleles, normal risk of celiac disease and lupus.
no HLA-DQ8 haplotype, normal (lower) risk of Celiac disease.
No risk variants in CCR3
No risk variants in IL18R1
AA in rs13119723, lower (normal) risk for celiac disease. 0 risk variants
1 risk variant in R262W
Allergies Panel
GG in rs62623409, typical odds of allergic sensitivity
AA in rs2367563, nickel likely causes an allergic skin reaction.
GG in rs2155219, 0 alleles for higher odds of allergies. Odds Ratio for every T allele = 1.18
CC in rs17513503, lower odds of allergies; common
GT in rs7192, somewhat (1.7x) increased risk of developing a peanut allergy. Risk variant is T.
TT in rs9275596, lower risk of peanut allergy. Risk allele is C.
Androgen Receptor Gene (AR) Panel
CC in rs137852591, very typical ; no Androgen insensitivity.
GG in rs9332969, normal , no Reifenstein syndrome.
GG in rs9332971, normal , no Reifenstein syndrome.
Crohn's Disease Panel
CC in NOD2's Arg702Trp. Typical (lower) risk for Crohn's disease.
Canavan Syndrome Panel
GG in rs104894553, 0 risk variants.
If you have more than 0 risk variants for Canavan syndrome, that is cause for concern. May be the result of genotyping errors depending on the chip you tested with.
HIV & AIDS Panel
HIV does not develop and transition into AIDs the same way with every organism. Some are predisposed to larger viral load and quicker compromisation of the immune system while others are more resistant.
0 protective variants in rs9264942 (Bad), typical genotype.
common (Good), no risk variants in rs2395029 (TT )
GG in rs2572886, Good , 0 risk variants (A), common.
HLA Gene Panel
The HLA genes are located on chromosome 6 in humans and encode proteins called human leukocyte antigens (HLAs). These proteins play a vital role in immune responses by presenting antigens to immune cells, specifically T cells. There are two main classes of HLA proteins: class I and class II.
The HLA system plays a critical role in several medical contexts, including organ transplantation, where matching HLA types between donor and recipient is crucial to minimize the risk of rejection. Additionally, HLA genes are associated with susceptibility to certain autoimmune diseases, infectious diseases, and drug hypersensitivity reactions, making them important targets for medical research and personalized medicine.
Highest odds of Autoimmune Disease 1.818 %
Intermediate (Slightly higher) Odds of Autoimmune Disease 40.000 %
Lower Odds of Autoimmune Disease 58.182 %.
MTRR Gene Panel
AG in rs1801394, slightly higher odds for meningomas and neural tube defects. 1 risk allele for disorders of Intracellular Cobalamin Metabolism
CC in rs10380, lower odds of pancratic cancer; 0 risk alleles for disorders of Intracellular Cobalamin Metabolism
AA in rs162036, no risk variants for spina bifida & Disorders of Intracellular Cobalamin Metabolism.
CC in rs2287780, no risk variants for Disorders of Intracellular Cobalamin Metabolism
TT in rs2303080, 0 risk alleles for disorders of Intracellular Cobalamin Metabolism
AG in rs1802059, 1 risk allele for disorders of Intracellular Cobalamin Metabolism
CT in CBS's rs234709, slightly decreased homocysteine levels
Predisposed to higher levels of Plasma homocysteine, CC in rs6586282
Predisposed to intermediate levels of Plasma homocysteine, CT in rs2851391, T allele leads to lower levels
homocystinuria Panel
We found Risk variants in : rs1789953(1) and a total of 1 risk variants for homocystinuria in CBS gene out of 10 variants identified in your file in total.
Elevated homocysteine levels 25.926 %
Intermediate homocysteine levels 51.852 %
Lower homocysteine levels 22.222 %.
Thyroid Cancer Panel
AG in rs965513, 1.77x increased thyroid cancer risk.
CT in rs944289, 1.3x increased thyroid cancer risk
CC in rs116909374, typical(lower) odds of thyroid cancer
CT in rs966423, one allele for Possible elevated thyroid cancer risk
CG in rs2439302, slightly below average odds of thyroid cancer. Risk allele for thyroid cancer is G
Muscular Dystrophy Myopathies
0 risk variants for Duchenne muscular dystrophy in rs1800278
0 risk alleles in rs2296949
0 risk variants in rs28937900
0 risk variants in rs193922094
Found : 1 risk variants for adrenoleukodystrophy out of 42 Total
If you have risk variants here, it is most likely caused by miscalls in your raw data.
Since ADL is an X-linked condition, males can not be carriers. If you are male over the age of 20 and see risk variants here, it is due to miscalls. Otherwise you would be dead.
Colorblindness Panel
0 risk variants in OPN1LW out of 4
0 risk variants in OPN1MW out of 0
1 risk variants in OPN1SW out of 4
FTO Gene Panel
1 risk allele (G) for obesity in rs9930506, slightly higher than average risk of obesity
Heterozygous in rs1421085, 1.3x higher risk of obesity
AT , 1 'fat gene' variant in FTO's rs9939609. Higher odds of obesity and sleep apnea.
Within PFKP Gene - also implicated in Obesity
GG in rs6602024, lower BMI
Others also implicated in Obesity
AA in rs4994, typical genotype - lower odds of obesity.
CT in rs6232, slightly higher risk of obesity and insulin sensitivity
Syncope Panel
A syncope, commonly known as fainting, is a temporary loss of consciousness and muscle tone caused by a brief reduction in blood flow to the brain. This sudden and temporary loss of consciousness typically results from a drop in blood pressure, leading to a momentary interruption of oxygen and nutrient supply to the brain. Syncope episodes are often brief, lasting only a few seconds to a couple of minutes, and individuals usually recover spontaneously once blood flow is restored. Various factors, such as dehydration, low blood sugar, or sudden changes in body position, can contribute to the occurrence of syncope.
GG in rs1431318, ~7% decreased odds of syncope.
Used 1 snps in the following prediction
Syncope risk is 0.930 times the average
Bio Traits Panel
GG in MTR's rs1805087, increased MTR activity and likely decreases homocysteine levels (doesn't contribute to homocysteine panel score)
CT in rs174528, intermediate levels of omega 3 fatty acid, intermediate levels of docosahexaenoic acid - T allele increases levels
CT in rs174547, one allele for lower resting heart rate (C), one allele for lower omega-6 & omega-3 levels (C), common genotype
ACE I/D genotype, increased ACE activity - healthier, reduced odds of hypertension and a range of other issues.
CT in rs1544410, Intermediate risk of low bone mineral density disorders
GG in rs1051730, Smokes normal (lower) number of cigarettes if a smoker, reduced odds of lung cancer.
rs5443 (TT) are clearly at higher risk for hypertension, 2-3 fold more likely to be obese, rs5443(T;T) genotypes respond to Viagra better. rs5443(T;T) patients receiving clozapine over a long term for the treatment of schizophrenia gain significantly more weight (16%) compared to patients carrying at least one rs5443(C) allele in a study of Chinese patients. rs5443(T) carriers taking triptans for the treatment of migraines or cluster headaches were ~3 fold more likely to respond positively compared with rs5443(C;C) homozygotes (OR 2.96, CI:1.34 - 6.56, p=0.0074) in a study of ~200 Caucasian patients.
AG in CDH4's rs16985493, unusual genotype associated with ~1.3x increased odds of migraine.
TT in rs185819, ~30mm shorter
CC in rs1042725, ~0.8cm taller height relative to TT genotype
TT in rs6060369, ~0.88cm shorter height relative to CC genotype
AA in rs10946808, taller.
GG in rs1800795, more IL6, significantly associated with type-2 diabetes (odds ratio 1.51)
AG in rs1380703, shorter sleep duration, likely European or East Asian
GG in rs66800491, lower (typical) odds of motion sickness (This is the variation with highest impact for motion sickness)
CC in rs2148710, lower predisposition to anger
Wet earwax. Normal (smellier) body odour. Normal colostrum. Typical for non-East Asians. CC in rs17822931
Two copies of "hunter-gatherer" CLTCL1 gene variant. Reduced ability to process carbs and sugars.
CT in rs307377, extra tasting ability
AA in rs662799, normal (Lower odds of heart attack and obesity)
CC in rs27072, 2x risk of severe alcohol withdrawal. Possible increased odds of ADHD
AG in rs4481887, more likely to be able to smell asparagus metabolites in urine
AG in rs6591536, more able to detect β-ionone (floral) fragrance
AG in rs11800854, much lower (x0.1) odds of periodontitis
GG in rs234706, no alleles for reduced odds of cleft palate
Age Related Macular Degeneration
TG in rs547154, 0.47x decreased risk for Age-related maculopathy, uncommon genotype. The rare protective allele is T.
AC in rs1061147 , Normal 0.97x risk for Age Related Macular Degeneration. (risk allele is A)
GG in rs11200638, normal risk of age related macular degeneration
GG in rs2230199, normal (reduced) risk for AMD
CG in rs380390, higher odds of AMD, risk allele is C
CC in rs3793917, lower (typical) odds for AMD
AG in rs800292, increased odds of Age-related macular degeneration (MTAG)
Cataracts Panel
GG in rs62621812, typical genotype, lower (typical) risk for cataracts.
GG in rs1929494, slightly reduced (~0.93x) risk for cataracts.
Vitamins and Levels
TG in rs2282679 of GC gene, likely lower levels of Vitamin D. ⚠
AC in rs7041, one allele for reduced vit D levels (A), intermediate odds for COPD if you smoke - average levels of vitamin D ⚠
TT in rs12785878, lower levels of Vitamin D. ⚠
AA in rs10741657, tend to have higher vitamin D levels
TT in rs7129781, decreased odds of Vitamin D insufficiency
TG in rs4961 (imputed through rs4963), 1.8x increased risk for high blood pressure
AG in rs4895441, intermediate red blood cell count ⚠
CC in rs140522, lower red blood cell count ⚠
AC in rs1063739, slightly lower protection of neurons against glutamate toxicity, slightly decreased (normal) rate of glutamate degradation. Risk allele is A. ⚠
AA in rs602662, Higher vitamin B12 levels. 49.77 pg/ml increase per A allele relative to GG genotype
CC in rs34324219, higher (Typical) vitamin B12 levels.
TT in rs4654748, 1.45 ng/ml increase in B6 levels
CC in rs33972313, typical (higher) levels of Vitamin C
Predisposed to lower levels of Vitamin A/Retinol, CC in rs780093 ⚠
AG in rs11057830, rare genotype leading to higher level of Vitamin E, rare allele is A.
GG in rs6862909, typical genotype, higher - typical Vitamin K levels
CC in rs964184, typical (lower) levels of vitamin K ⚠
CC in ARSD's rs1637781, higher Ascorbic acid 3-sulfate levels
DVT Panel
CT in rs11121615, average odds of varicose veins. The 'good' allele is T. Highest pval and beta snp for this trait
CC in rs6025, lower (normal) risk of deep vein thrombosis
GG in rs1799963, lower risk of deep vein thrombosis
AG in rs113092656, higher (x1.3) risk of deep vein thrombosis, risk allele is A
GG in rs7025486, lower odds of aneurysm and vascular disorders
Blood Group Panel
CC in rs9919007, likely blood type A or O. 0.74 accuracy
CC in rs635634, higher odds for all blood types besides A. 0.92 accuracy
TT in rs8176720, likely A or O blood type. 0.77 accuracy
GG in rs7030248, Likely no Blood type B or AB. Accuracy 0.74
TT in rs493014, no blood type B or AB. Accuracy 0.75.
GG in rs687289, Likely not Blood type AB. Accuracy 0.91
GG in rs8176746, likely not blood type AB. Accuracy 0.75.
TT in rs505922, Likely blood type O. 0.8 accuracy
TT in rs529565, Likely blood type O. 0.98 accuracy
AA in rs8176740, slightly lower odds of B and O blood types
